A Novel One-Pot Synthesis of PVP-Coated Iron Oxide Nanoparticles as Biocompatible Contrast Agents for Enhanced T2-Weighted MRI

A contrast agent with specific characteristics is essential for high-quality magnetic resonance imaging (MRI). It plays a crucial role in enhancing the visibility of certain tissues and structures, making it imperative diagnostic procedures. Superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as promising alternative to traditional agents MRI due their non-toxicity superior properties. However, suitable surface coating strategy needed produce polymer-coated SPIONs controllable sizes order enhance stability biocompatibility. This study presents novel one-pot synthesis method production highly stable polyvinylpyrrolidone (PVP)-coated SPIONs. By systematically manipulating physicochemical properties SPIONs, effect different molecular weights PVP was studied. The results showed that coated wight 40,000 g/mol (40 K) exhibited high magnetization (Ms = 48.4 emu/g), an average size distribution (11.61 nm), excellent stability. relaxivity uncoated investigated using images. revealed (r2/r1) ratio PVP40K-SPIONs 72.55, compared 55.72 bare them T2-contrast future development applications. opens new avenues biocompatible improved medical imaging.